^ Blum K, Werner T, Carnes S, Carnes P, Bowirrat A, Giordano J, Oscar-Berman M, Gold M (2012). "Sex, drugs, and rock 'n' roll: hypothesizing common mesolimbic activation as a function of reward gene polymorphisms". Journal of Psychoactive Drugs. 44 (1): 38–55. doi:10.1080/02791072.2012.662112. PMC 4040958. PMID 22641964. It has been found that deltaFosB gene in the NAc is critical for reinforcing effects of sexual reward. Pitchers and colleagues (2010) reported that sexual experience was shown to cause DeltaFosB accumulation in several limbic brain regions including the NAc, medial pre-frontal cortex, VTA, caudate, and putamen, but not the medial preoptic nucleus. Next, the induction of c-Fos, a downstream (repressed) target of DeltaFosB, was measured in sexually experienced and naive animals. The number of mating-induced c-Fos-IR cells was significantly decreased in sexually experienced animals compared to sexually naive controls. Finally, DeltaFosB levels and its activity in the NAc were manipulated using viral-mediated gene transfer to study its potential role in mediating sexual experience and experience-induced facilitation of sexual performance. Animals with DeltaFosB overexpression displayed enhanced facilitation of sexual performance with sexual experience relative to controls. In contrast, the expression of DeltaJunD, a dominant-negative binding partner of DeltaFosB, attenuated sexual experience-induced facilitation of sexual performance, and stunted long-term maintenance of facilitation compared to DeltaFosB overexpressing group. Together, these findings support a critical role for DeltaFosB expression in the NAc in the reinforcing effects of sexual behavior and sexual experience-induced facilitation of sexual performance. ... both drug addiction and sexual addiction represent pathological forms of neuroplasticity along with the emergence of aberrant behaviors involving a cascade of neurochemical changes mainly in the brain's rewarding circuitry.
Drug addiction is a condition that is characterised by repeatedly taking or administering drugs - whether these are illegal drugs such as heroin, cocaine, or MDMA/ecstasy, or legal prescription drugs - to the extent that you become both physically and psychologically dependent on these substances. Regardless of the type of drug addiction that you have developed, continued drug use can soon become a serious problem and can lead to a range of serious long-term consequences, and may even be fatal.
Drug addiction is a growing concern in the United States. People often use drugs as an outlet for their problems, although drug use creates its own problems over time. Drug addiction not only affects a person’s health and relationships, but also impacts society and the environment. There are numerous treatment options to guide people toward a sober and healthy life.
Getting alcohol out of the addicted person’s system is the first part of recovery. People with a severe alcohol addiction can experience intense withdrawal symptoms. A supervised alcohol detox is usually necessary for people addicted to alcohol to prevent potentially fatal complications. Shaking, sweating, seizures, and hallucinations are possible alcohol withdrawal symptoms. Alcohol Rehabilitation Centers - What is it like going to in Rehab
^ Jump up to: a b "Substance use disorder". Pubmed Health. National Institutes of Health. Archived from the original on 31 March 2014. Retrieved 12 September 2014. Drug dependence means that a person needs a drug to function normally. Abruptly stopping the drug leads to withdrawal symptoms. Drug addiction is the compulsive use of a substance, despite its negative or dangerous effects Drug and Alcohol Treatment Centers ► The Problem With Relapse
As with other diseases and disorders, the likelihood of developing an addiction differs from person to person, and no single factor determines whether a person will become addicted to drugs. In general, the more risk factors a person has, the greater the chance that taking drugs will lead to drug use and addiction. Protective factors, on the other hand, reduce a person's risk. Risk and protective factors may be either environmental or biological.
Gateway Foundation is a national provider that has 17 convenient drug treatment centers in Illinois, Delaware and California to serve our patients in the places and communities they call home. We put our patients at the center of their substance abuse treatment—life-saving treatment that stays with them throughout their lives. Through individualized treatment, we’re able to help them discover what will work best for them in their journey to overcome drug and alcohol addiction. Brene Brown Knows! Toxic Shame & Trauma in Addiction Treatment w/ Gerald Loren Fishkin